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KMID : 0043320150380050876
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Archives of Pharmacal Research
2015 Volume.38 No. 5 p.876 ~ p.884
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Inhibitory effects of (?)-loliolide on cellular senescence in human dermal fibroblasts
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Yang Hyo-Hyun
Hwangbo Kyoung
Zheng Ming Shan
Cho Jung-Hee
Son Jong-Keun
Kim Hwa-Young
Baek Suk-Hwan
Choi Hyung-Chul
Park So-Young
Kim Jae-Ryong
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Abstract
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Cellular senescence influences tumor suppression and progress, tissue repair and regeneration, tissue and organismal aging, and age-related diseases. Aging intervention might be an advantageous target for prevention and treatment of diverse age-related diseases. In this study, we investigated whether (?)-loliolide purified from the crude extract of Polygonum aviculare exerted inhibitory activity against cellular senescence in human dermal fibroblasts (HDFs). (?)-Loliolide diminished senescence-associated β-galactosidase activity (SA-β-gal), the level of p21 protein, and the level of reactive oxygen species in senescent cells induced by adriamycin treatment. (?)-Loliolide also attenuated SA-β-gal activity in HDFs under replicative senescence. These findings imply that (?)-loliolide rescues cellular senescence in HDFs and might be useful for the development of dietary supplements or cosmetics that ameliorate tissue aging or age-associated diseases.
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KEYWORD
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(?)-Loliolide, Cellular senescence, Human dermal fibroblasts, Aging intervention
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